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- in India and Nepal since the Vedic period dating back to approximately 1500 BCE, but perhaps as far back as 2000 BCE.There are several references in Greek mythology to a powerful drug that eliminated anguish and sorrow.The same review found that greater dose of marijuana and earlier age at onset of use were also associated with such alterations.A 2010 review found resting blood flow to be lower globally and in prefrontal areas of the brain in cannabis users, when compared to non-users.These statistics include visits in which the patient was treated for a condition induced by or related to recent cannabis use.The drug use must be "implicated" in the emergency department visit, but does not need to be the direct cause of the visit.These putative effects can be taken in context of a wide range of cardiovascular phenomena regulated by the endocannabinoid system and an overall role of cannabis in causing decreased peripheral resistance and increased cardiac output, which potentially could pose a threat to those with cardiovascular disease.Cannabis use is associated with neuroanatomic alterations in brain regions rich in cannabinoid receptors, such as the hippocampus, prefrontal cortex, amygdala, and cerebellum.
At higher doses, effects can include altered body image, auditory and/or visual illusions, pseudohallucinations and ataxia from selective impairment of polysynaptic reflexes.
It was also shown that giving THC or cannabis correlated with increased bloodflow in these areas, and facilitated activation of the anterior cingulate cortex and frontal cortex when participants were presented with assignments demanding use of cognitive capacity.
Both reviews noted that some of the studies that they examined had methodological limitations, for example small sample sizes or not distinguishing adequately between cannabis and alcohol consumption.
Evidence for causing these cancers is mixed concerning heavy, long-term use.
In general there are far lower risks of pulmonary complications for regular cannabis smokers when compared with those of tobacco.